A biocompatible reverse thermoresponsive polymer for ocular drug delivery
نویسندگان
چکیده
منابع مشابه
Thermoresponsive graphene oxide – starch micro/nanohydrogel composite as biocompatible drug delivery system
Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-responsive materials, poly (N-isopropylacrylamide) (PNIPAAm) based hydrogels have been widely developed ...
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PURPOSE To characterize thermoresponsive hydrogels (liquids at room temperature, gels at body temperature) as a novel drug delivery platform to the posterior segment. METHODS Thermoresponsive hydrogels were synthesized using poly(N-isopropylacrylamide) (PNIPAAm), cross-linked with poly(ethylene glycol) diacrylate (PEG-DA). Proteins were then encapsulated into the hydrogels, including bovine s...
متن کاملThermoresponsive polymer membrane for the local delivery of drugs
1Faculty of Pharmacy, University of Toronto; 2Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario Correspondence and reprints: Dr BA Saville, Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5. Telephone 416-978-7745, fax 416-978-8605, e-mail [email protected] CC N...
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Statement of Purpose: Targeted drug delivery into the eye is a challenging task because of a variety of barriers that prevent safe and effective delivery. Topical application to the eye is hindered by low residence time resulting in poor diffusion of drug into intraocular tissues. Intravitreal injection can deliver drugs to the retina effectively but is invasive and carries risk of infection. I...
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A pharmacokinetic model of ocular drug delivery has been developed for describing the elimination and distribution of ocular drugs in the eye. The model, based on Fick's second law of diffusion, assumes a modified cylindrical eye with three pathways for drug transport across the surface of the eye: the anterior aqueous chamber, the posterior aqueous chamber and the retina/choroids/scleral membr...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2019
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2019.1587042